Atypical femur fractures associated with bisphosphonates: from prodrome to resolution
نویسندگان
چکیده
منابع مشابه
Atypical femur fractures associated with use of bisphosphonates and denosumab.
progression [2]. In addition, the time gain is very large in cancers for which the response rate is used as a surrogate end point such as hematological malignancy [3]. Second, we are not discussing a surrogate end point for less serious disease like cardiovascular disease [4], but are discussing a surrogate end point supporting clinical trials of innovative new drugs of high unmet medical need ...
متن کاملBisphosphonates and Atypical Fractures of Femur
Bisphosphonates are the most widely prescribed medicines for the treatment of osteoporosis and have generally been regarded as well-tolerated and safe drugs. Since 2005, there have been numerous case reports about atypical fractures of the femur linked to long-term treatment of osteoporosis with bisphosphonates. Some attempts to characterize pathophysiology and epidemiology of these fractures h...
متن کاملAtypical Fractures of the Femur Associated with Chronic Treatment with Bisphosphonates.
BACKGROUND The problem of atypical fractures, such as subtrochanteric or diaphyseal femoral fractures, associated with long-term treatment with bisphosphonates (BPs) has recently been given increasingly more attention. These fractures develop as stress fractures and are characterised by diaphyseal cortical thickening and a transverse or slightly oblique fracture line. The use of bisphosphonates...
متن کاملBisphosphonates and atypical subtrochanteric fractures of the femur
OBJECTIVES Bisphosphonates are widely used as first-line treatment for primary and secondary prevention of fragility fractures. Whilst they have proved effective in this role, there is growing concern over their long-term use, with much evidence linking bisphosphonate-related suppression of bone remodelling to an increased risk of atypical subtrochanteric fractures of the femur (AFFs). The obje...
متن کاملAtypical fractures of the femur related to prolonged treatment with bisphosphonates for osteoporosis.
BACKGROUND Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphosphonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients may therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft. O...
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ژورنال
عنوان ژورنال: Rheumatology Reports
سال: 2015
ISSN: 2036-752X,2036-7511
DOI: 10.4081/rr.2015.6068